Molecules | Free Full-Text | Weinreb Amides as Directing
Molecules | Free Full-Text | Weinreb Amides as Directing Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific Publication – Huang Group 15. Traceless Directing Strategy Efficient Synthesis of N-Alkyl Indoles via Redox-Neutral C–H Activation Chengming Wang and Yong Huang*, Org. Lett. 2013, 15, 5294-5297. A general protocol for the synthesis of N-alkyl indoles has been developed via a redox neutral C–H activation strategy using a traceless nitroso directing group. Stereodivergent synthesis of 1,4-dicarbonyls by traceless Aug 17, 2018 Marc Font - Postdoctoral Research Fellow - Universidad de
Single Electron Activation of Aryl Carboxylic Acids: iScience
Starting with salicylic acid and an iodoarene, the group first identify efficient conditions for the arylation–decarboxylation process. Using the pyridine-stabilised PEPPSI-IPr pre-catalyst Carboxylic Acids as A Traceless Activation Group for
Jan 28, 2015
The Supersilyl Group as a Carboxylic Acid Protecting Group: Application to Highly Stereoselective Aldol and Mannich Reactions. Borylation of the nitrogen in nitrogen heterocycles or anilines provides a traceless directing group for subsequent catalytic C-H borylation. Selectivities that previously required Boc protection can be achieved